Photochemistry for Biomedical Applications

Photochemistry for Biomedical Applications

From Device Fabrication to Diagnosis and Therapy

Springer Verlag, Singapore






15 a 20 dias

Versão ebook 99,99 €

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Part I Photochemistry and photo-fabrication Chapter 1 Photochemistry 1-1 Introduction 1-2 Photochemistry 1-2-1 Energy diagram 1-2-2 Electronic structures 1-2-3 Electronic transition 1-2-4 Absorption and excitation spectra 1-2-5 Photochemical reactions 1-2-5-1 Reactions 1-2-5-2 Sensitizer 1-3 Light source 1-4 Light and medicine Chapter 2 Photochemical processed materials 2-1 Photochemical processes for polymeric materials 2-1-1 Photo-polymerization 2-1-1-1 Polymerization mechanism 2-1-1-2 Photo-initiators 2-1-1-3 Visible-light initiators 2-1-1-4 Macromolecular photoinitiator 2-1-1-5 Photo-iniferter 2-1-2 Photo-reactive polymers 2-1-2-1 Photo-reactive groups 2-1-2-2 Photo-reactive polymer by polymerization A Synthetic polymers B Natural polymers 2-2 Photo-degradation Chapter 3 Photo-fabrication 3-1 Introduction 3-2 Planar fabrication and 2D structuring 3-2-1 Micro-patterning 3-2-2 Undeformative processing 3-2-3 Additive processing 3.2.3.A Surface modification "Grafting-to" "Grafting-from" Controlled/living grafting Photo-iniferter graft polymerization Topological 2D patterning 3.2.3.B Deposition and transfer of biomaterials Pulsed laser deposition (PLD) Laser-induced forward transfer (LIFT) 3.2.4 Substrate processing Photo-ablation Surface nano-structuring 3-3 3D structure and volume processing 3.3.1 Stereolithography 3.3.2 Ultrafast laser 3D fabrication 3.3.2.A Principle of 3D fabrication by ultrafast laser 3.3.2.B Undeformative 3D fabrication 3.3.2.C Subtractive 3D fabrication 3.3.2.D Additive 3D fabrication (two-photon polymerization) Medical and tissue engineering applications 3D printing of proteins 3.3.2.E Hybrid 3D fabrication 3-4 Conculsions Part II Applications for diagnostics Chapter 4 Microarray chips (in vitro diagnosis) 4-1 introduction 4-2 Microarrays for gene analysis 4-3 Microarrays for protein analyses 4-4 Other Microarrays 4-5 Automated Systems Chapter 5 Clinical Diagnostic Imaging 5-1 Introduction 5-2 Targeting 5-2-1 Targeting methodology for clinical image diagnosis 5-2-2 Contrast agent targeting for clinical image diagnosis 5-2-3 Characteristics of photochemical contrast agent systems 5-3 Carriers used for imaging diagnosis 5-3-1 Polymeric materials 5-3-2 Dendrimers 5-3-3 Liposomes 5-3-4 Polymeric micelles 5-3-5 Metal nanoparticles a Quantum dots b Silica nanoparticles c Gold nanoparticles d Iron oxide nanoparticles 5-4 Applications of optical imaging 5-4-1 Categories of optical imaging agents for medical diagnoses 5-4-2 Recent advanced developments in optical techniques for imaging diagnoses 5-4-3 Near-Infrared fluorescence (NIRF) imaging A Non-targeted contrast agents B Non-targeted activatable agents C Targeted agents D Clinical applications 5-4-4 Photoacoustic tomography 5-4-5 Raman spectroscopy (surface-enhanced Raman spectroscopy, SERS) Part III Applications for therapeutics Chapter 6 Surface modification for medical devices 6.1 Introduction 6.2 Non-biofouling/biofouling micropatterned surface 6.2.1 Synthetic polymer Amphiphilic polymer Cell spreading and adhesive areas Cell geometry Cell protrusion Cell density and cell-cell interaction Cell orientation Zwitterionic polymer Stimuli-responsive polymer 6.2.2 Natural polymer Protein Polysaccharide 6.3 Biologically active surfaces 6.3.1 Cell adhesion enhancement 6.3.2 Cell growth enhancement Direct immobilization of growth factor Indirect immobilization of growth factor 6.3.3 Other cellular activations Neural extension Differentiation With biosignaling molecules Without biosignaling molecules Stem cell culture Chapter 7 Dental resin 1. Introduction 2. The structure of tooth 3. The history of dental resin developing 4. The dental adhesive resin 5. Curing system 6. Toxicity of dental resin 7. Research opportunities Chapter 8 Bioadhesives and Biosealants 1. Introduction 2. UV curable 2.1 Synthetic polymer 2.1a Acrylate-based 2.1b Epoxy-based 2.1c Thiol-ene-based 2.2 Natural polymer 2.2a Protein 2.2b Polysaccharide i) Hyaluronic acid ii) Alginate iii) Chitosan iv) Dextran 3 Visible light curable 3-1 Synthetic polymer 3.2 Natural polymer 3.2a Protein 3.2b Polysaccharide 3.3c Direct curing with dye 4 Infrared curable Chapter 9 Drug delivery systems 9-1 Introduction 9-2 Photo-crosslinkable system 9-2-1 Synthetic polymers Non-biodegradable polymers Biodegradable polymers 9.2.2 Natural polymers 9-2-2-1 Protein-base 9-2-2-2 Polysaccharide-base 9-3 Photo-triggered release system 9.3.1 Non-photodegradable matrix UV/visible system Photothermal system 9.3.2 Photo-degradable Matrix degradable Main chain Crosslinker Side chain NIR 9.4 Mutiple-triggered release system Chapter 10 Photo-crosslinkable Hydrogels for Tissue engineering Applications 1. Introduction 2. Artificial and acellular scaffold 2.1 Gel or prosthesis 2.2 Solid matrix 3. Cell-laden scaffold Chapter 11 Photodynamic therapy 1. Polymer for photodynamic therapy 2. Targeting tumor through enhanced permeability and retention effect (EPR effect) 3. Polymer design for EPR effect 4. Polymer design for active targeting 5. Conclusion
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